The Twins didn't fare well on offense or from the mound in the season debut of starter Samuel Deduno on Friday night.
Anibal Sanchez lost his no-hit bid to a Joe Mauer single in the ninth, and the Tigers racked up 11 hits and six runs.
But Minnesota will be hoping Saturday's starter, also taking the hill for them for the first time this year, won't fall victim to that same fate.
P.J. Walters will get the ball for the Twins against the Tigers on Saturday at Comerica Park, taking on the Tigers' Doug Fister as Detroit aims to secure the series win.
Walters started nine games with Triple-A Rochester, posting a 3.31 ERA with 46 strikeouts and 16 walks in 54 1/3 innings. He'll try to best a red-hot Tigers offense, which leads the American League in batting average and runs scored.
Miguel Cabrera had homered in four straight games before Friday night, and went 1-for-4 with two RBIs off Deduno and company.
"[Cabrera] doesn't throw any at-bats away anymore, and I'm proud of him for that," Tigers manager Jim Leyland said Tuesday. "Because we talked about that a couple years ago. He's a hard guy to get out. No matter when he's up there, no matter what the situation is, he's a tough guy to get out. When he grinds that at-bat out, it's something to see."
Twins: Minnesota keeps slumping
• The Twins have lost 10 games in a row, their longest losing streak since September 2011. They've gone 0-5 to open a nine-game road trip.
"It just seems like we played really well and just had a lot of bad breaks," pitcher Scott Diamond said Thursday. "But good teams have to come back and fight. And we're still showing fight, so as deflating as it is right now, I guarantee you we'll keep fighting tomorrow."
• The Twins bullpen allowed four runs on Thursday, the first runs it surrendered to the Tigers in 15 2/3 innings. Minnesota's relievers were solid Friday, however, throwing 2 2/3 innings and being charged with two hits and no earned runs while striking out four.
Tigers: Detroit bats stay hot
• Miguel Cabrera has at least two RBIs in each of his last five games. If he has a multi-RBI game Saturday, he will tie a Tigers record that dates back to 1940.
"The numbers are unbelievable. The hardest part about that lineup is they have so many great hitters," Twins manager Ron Gardenhire said. "Fielder is an MVP guy himself. So it's kind of like flip a coin. You tell yourself not to let Miggy beat you, but then the next guy will."
• The Tigers are 48-18 at Comerica Park since July 4, 2012, the best mark in the baseball in that stretch.
• Fister is 3-6 in his career against the Twins, but owns a 3.13 ERA. He has struck out 49 and walked 10 in 60 1/3 innings.
• Cabrera has 27 career home runs against Minnesota, his second most against a single team. He's hitting .324 lifetime against the Twins.
• Justin Morneau has reached base safely in 14 of his last 16 games at Comerica Park.
Steven Petrella is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.